Malignant phyllodes tumor in a patient with hereditary retinoblastoma: a case report and literature review

Damon D. Shearer, Department of Radiology, University of Iowa Hospitals and Clinics, Iowa City, Iowa
Ryan W. Askeland, Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, Iowa
Jeong MI Park, Department of Radiology, University of Iowa Hospitals and Clinics, Iowa City, Iowa
Laurie L. Fajardo, Department of Radiology, University of Iowa Hospitals and Clinics, Iowa City, Iowa
Limin Yang, Department of Radiology, University of Iowa Hospitals and Clinics, Iowa City, Iowa

Abstract

Patients with hereditary retinoblastoma are at increased risk for second malignancies, most notably sarcomas, particularly after treatment with radiation. Malignant phyllodes tumor is a rare secondary malignancy in these patients. We present a review of the literature and report of a patient with hereditary retinoblastoma who developed two secondary malignancies, including malignant phyllodes tumor. The patient’s phyllodes tumor presented as a palpable breast mass with suspicious findings on mammogram and ultrasound. The mass was shown to be at least a borderline phyllodes tumor via sonographic percutaneous biopsy and confirmed malignant phyllodes tumor on final surgical excision.

 

URL

https://ir.uiowa.edu/pog_in_press/15