Document Type

Article

Peer Reviewed

1

Publication Date

1-1-2014

NLM Title Abbreviation

J Neurodev Disord

Journal/Book/Conference Title

Journal of Neurodevelopmental Disorders

PubMed ID

24669826

DOI of Published Version

10.1186/1866-1955-6-6

Abstract

Background Autism and the fragile X syndrome (FXS) are related to each other genetically and symptomatically. A cardinal biological feature of both disorders is abnormalities of cerebral cortical brain volumes. We have previously shown that the monoamine oxidase A (MAOA) promoter polymorphism is associated with cerebral cortical volumes in children with autism, and we now sought to determine whether the association was also present in children with FXS. Methods Participants included 47 2-year-old Caucasian boys with FXS, some of whom also had autism, as well as 34 2-year-old boys with idiopathic autism analyzed in a previous study. The MAOA promoter polymorphism was genotyped and tested for relationships with gray and white matter volumes of the cerebral cortical lobes and cerebro-spinal fluid volume of the lateral ventricles. Results MAOA genotype effects in FXS children were the same as those previously observed in idiopathic autism: the low activity MAOA promoter polymorphism allele was associated with increased gray and white matter volumes in all cerebral lobes. The effect was most pronounced in frontal lobe gray matter and all three white matter regions: frontal gray, F = 4.39, P = 0.04; frontal white, F = 5.71, P = 0.02; temporal white, F = 4.73, P = 0.04; parieto-occipital white, F = 5.00, P = 0.03. Analysis of combined FXS and idiopathic autism samples produced P values for these regions

Keywords

OAfund, Autism, Fragile X syndrome, Brain structure, Monoamine oxidase A, Polymorphism

Journal Article Version

Version of Record

Published Article/Book Citation

Journal of Neurodevelopmental Disorders 6:1 (2014) pp. 1-9. doi:10.1186/1866-1955-6-6

Rights

Copyright: © 2014 Wassink et al.; licensee BioMed Central Ltd.

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution 3.0 License.

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Psychiatry Commons

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URL

https://ir.uiowa.edu/psychiatry_pubs/1